Factor XIIa initiates the HAE pathway that leads to attacks in someone with HAE

Factor XIIa (pronounced “Factor 12-a”) is a protein that occurs naturally in your body. In hereditary angioedema (HAE), it initiates the HAE pathway.

If the HAE pathway is not regulated, it leads to an attack

Graphic: The pathway that leads to an HAE attack—how it all gets started

No treatment today targets Factor XIIa

Not one of the treatments available today targets Factor XIIa―the top of the HAE pathway.

Graphic: The pathway that leads to an HAE attack—how it all gets started

Factor XIIa plays a critical role in the HAE pathway

Doctor Discussion Guide download icon

Talk to your doctor about your HAE

This guide can help you discuss your experience with HAE and the pathway that leads to attacks.

DOWNLOAD THE GUIDE

Download the Guide icon